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Nutritional status The HFR, despite increasing the elimination of uremic toxins and inflammatory markers, minimizes the loss of nutrients such as amino acids and vitamins with respect to high-flux HD and OL-HDF, which are associated with a loss amino acid l of 45 g/per session.75 In small studies It has been proven that the elimination of both essential and branched amino acids is lower with HFR than with acetate-free HDF, probably due to the absence of amino acid adsorption by the cartridge and the endogenous reinfusion of plasma.67 Another small randomized study showed less vitamin C losses in 41 patients using the HFR technique,76 while several studies have shown less albumin loss associated with HFR compared to OL-HDF.44,45,63 The reduced loss of amino acids, vitamins and albumin postulates HFR as a technique of great use in malnourished patients with nutritional supplementation requirements

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The exact reason for skin reactions from alpha lipoic acid isnt clear

10.1016/j.biopha.2020.110074 56 LiD.LiuS.XuJ.ChenL.XuC.ChenF.et al (2021)

More isn't better with hyaluronic acid consistent, appropriate amounts yield the best outcomes