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GHK-Cu (glycyl-L-histidyl-L-lysinecopper) is a naturally occurring tripeptidea molecule made of three amino acidsthat has a powerful ability to bind copper ions (specifically copper(II))

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[57] In neuronal progenitor cells, DNA damage is associated with increased secretion of amyloid beta proteins A40 and A42

Although the causal relationship between smoking and the pathogenesis of AA has not been fully established, cigarette smoke has been shown to promote the production of proinflammatory cytokines while decreasing levels of anti-inflammatory cytokines (Dai et al., 2020)