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ParaHydrogen Induced Polarization (PHIP) methods exploit the spin order of the parahydrogen singlet state that can be converted into observable magnetization through fast chemical reactions across unsaturated chemical bonds adjacent to 13 C carboxyl or 15 N nuclei of the labelled substrate [132]

Since only early diagnosis and timely therapy can effectively prevent long-term complications in patients with homocystinuria, many newborn screening programs worldwide target CBS deficiency [43]

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