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smallpox vaccine is highly effective from the acute administration within seven days of likely exposure, among those that can safely take the vaccine and are assuredly within the 7 days, means that uninfected, or perhaps even the early-infected cell populations, can rapidly produce sufficient quantities of IL-12, IL-18, IFNy, and factors to stimulate NK cells, and Variola-specific CTL's to overcome the viral evasion proteins and stop the infection in this early phase

Endocrinology 152 , 36383647 (2011)

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

Br J Clin Pharmacol (2022) 88(4):1598612

Because bulk cytosolic readouts obscure compartmental signals, measurement should rely on ER-targeted genetically encoded H 2 O 2 probes (e.g., roGFP-Orp1 or HyPer-ER), which report local peroxidatic events without cytosolic averaging and allow discrimination of ER-confined redox dynamics from extra-ER sources (Rashdan and Pattillo 2020