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However, the narrow therapeutic window and BBB penetration are significant translation challenges

doi: 10.1016/j.bbrc.2007.01.076 62 YoneyamaSKawaiKTsunoNHOkajiYAsakageMTsuchiyaTet al

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Available from: Altieri B, Muscogiuri G, Barrea L, Mathieu C, Vallone CV, Mascitelli L, et al

433 Recently, it was found that infants with reduced levels of Bifidobacterium and Faecalibacterium have elevated relative risk of asthma, characterized by elevated amounts of IL-4 + Th2 cells and reduced Treg levels, 434 attenuating the adaptive immune response