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In regard to functional capability, it has been reported that Chac1 functions as a -glutamyl cyclotransferase that specifically degrades glutathione by its catalytically active residue at E116 in the mouse and E115 in the human protein 30,34,35

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Neurochem Int 30:549555

While hypothalamic GHRH promotes growth hormone release, the hypothalamus also produces growth hormone inhibiting hormone (also known as somatostatin ) which inhibits growth hormone secretion

Glutathione-scavenging poly(disulfide amide) nanoparticles for the effective delivery of Pt(IV) prodrugs and reversal of cisplatin resistance