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All these mechanisms lead to MS-like motor symptoms observed in patients with Cbl deficiency such as subacute degeneration of the spinal cord [84]

Of note, this experiment and similar ones below were ended at around two weeks after challenge since persisting low-level rLCMV/LASV LIV C viremia in a subset of HkiL+LASV LII A animals was associated with mutations at amino acid 114 of the viral GPC, which corresponded to known KL25 escape mutations in LCMV-GPC 70 (Figure S4A, B)

Both compounds share a proposed mechanism of action and are considered structurally similar