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PLoS One 11 e0157860 Quinlan CL, Perevoshchikova IV, Hey-Mogensen M, Orr AL and Brand MD 2013 Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

In the CNS, IGF-1 has dual origins: one from the bloodstream, exerting endocrine effects upon entry into the CNS, and the other locally synthesized within the CNS, exerting autocrine/paracrine effects [25, 26]

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Miguel CA, Noya-Riob MV, Mazzone GL, Villar MJ, Coronel MF (2021) Antioxidant, anti-inflammatory and neuroprotective actions of resveratrol after experimental nervous system insults