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For example, lactate upregulates the expression of the deubiquitinase USP34 in HCC cells, increasing the expression of resistance-associated efflux proteins, such as MRP1 and P-gp, and contributes to both primary and acquired drug resistance

5 Conclusion Our in-vivo experimental model has for the first time confirmed that CPI2 can effectively reduce the swelling induced by MSU crystals in mice

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A rat model of progressive nigral neurodegeneration induced by the Parkinsons disease-associated G2019S mutation in LRRK2

Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling