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Furthermore, therapeutic efficacy is substantially restricted by rapid donor clearance from target sites and H 2 S volatilization, leading to unpredictable concentration decay in physiological solutions

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Lipoperoxidation is the main biochemical event during ferroptosis, which requires high amounts of free Fe 2+ in the cytosol to generate ROS by Fenton reaction [74]

Although randomized studies have not shown an overall effect on the frequency of exacerbations, a post-hoc analysis of a clinical trial reported a decrease in their severity (87) Overall, these results demonstrate that A1PI augmentation therapy offers significant benefits in slowing the progression of emphysema and improving clinical outcomes for patients with AATD, underscoring the importance of timely and continuous treatment