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Among the most widely used mechanisms are reduction-sensitive disulfide (-SS-) and diselenide (-SeSe-) linkages, which can be cleaved by intracellular GSH to activate drug release or imaging functions [16]

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The resulting precipitate was separated by centrifugation at 7.245 g for 10 min, dialyzed against dH 2 O, and dried at 60 C until a constant weight was achieved

As understanding of ferroptosis mechanisms deepens and multidisciplinary innovations progress, a multifaceted approach to targeting ferroptosis may ultimately emerge as a breakthrough for OA management by delaying disease progression and enhancing patients quality of life