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This matrix, combined with additional stabilizing ingredients like starch and tricalcium phosphate, forms a robust sucrosome carrier system (Figure 6)

308 Historically, a natural menopausal transition has been recognized as a life stage marked by gradually decreasing levels of estradiol (E2, the predominant ovarian estrogen) and progesterone accompanied by increasing levels of FSH and LH, beginning in earnest about two years before and stabilizing about two years after the last menstrual period