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This may be along with general COX 1 and COX 2 specificity (24), with the pyloric sphincter less sensitive to COX 2 and the lower esophageal sphincter more sensitive, but ultimately both affected by inhibition of both COX 1 and COX 2

Critics have questioned its accuracy and reproducibility, expressing concerns that excessive reliance on algorithms might lead to a narrow or oversimplified understanding of the complexity inherent in Chinese medicine [673, 674]

Figure 4 Statements Author contributions J-YM documented paper, drew figures, and summarized data

Ingesting a pill requires that it be digested through the digestive tract, which creates a less intense high and slower onset of withdrawal symptoms

doi: 10.3389/fnagi.2022.815347 35 MerloSCarusoGIBonfiliLSpampinatoSFCostantinoGEleuteriAMet al