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Thiazolidinediones (e.g., rosiglitazone and pioglitazone) enhance insulin sensitivity and reduce cardiac inflammation but are linked to side effects such as weight gain, edema, and bone fractures with long-term use (115, 116, 194)

Diferem do GH sinttico exgeno (somatotropina recombinante) por ativarem o eixo fisiolgico natural, promovendo liberao pulstil mais prxima do padro biolgico

Incorporated a 24-hour time window for accurate and timely identification of stage 2, 3, 4, or unstageable pressure injury present on admission

In the context of IRI, several distinctive patterns have emerged: cell-type specificity, where different cell populations exhibit distinct lactylation responses, notably demonstrated in hepatocyte HSPA12A-mediated regulation of HMGB1 lactylation [83]

Five groups of rats were established: control, ARNI, PQ (10 mg/kg), ARNI 68 + PQ, and ARNI 34 + PQ