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Additionally, Se exerts immunomodulatory effects by promoting macrophage polarization from pro-inflammatory M1 toward anti-inflammatory M2 phenotypes [21]

work showing that clock genes control G1/S progression by transcriptionally regulating Cdkn1a a gene encoding for the cyclin/Cdk inhibitor p12 WAF1/CIP1 and that alteration of circadian clock led to aberrant p21 expression and altered cellular proliferation 30

"Northwestern Health Sciences University ~ Diagnosis and Discussion"

Secondly, we would also like to extend appreciation to our colleagues, anesthesiologists, and intensivists: Vasiliy Zaharevich, MD, State Institution Minsk Scientific, and Practical Center for Surgery, Transplantology and Hematology, Mikhail Stryzhak, MD, Minsk Children's Infectious Diseases Hospital, and Katsiaryna Liakhouskaya, Minsk City Emergency Hospital for their valuable comments, practical observations, and great support

Isolation and quantification of RNA TRIzol reagent (16096020, Thermo Fisher Scientific, New York, USA) was used to extract total RNA