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Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile

Although clinical findings have revealed that osteoarthritic phenotypes are one of the common complications in patients with hemophilia (Braner, 2018), related pathogenesis and mechanisms of disease progression are yet to be fully understood

The GCLM subunit has no enzymatic activity but has an important regulatory function increasing the efficiency of the GCLC subunit

TDP-43 aggregates similarly compromise mitochondrial function, causing fragmentation and bioenergetic failure as organelles become trapped in the soma rather than distributing to distal motor neurone processes [101]

Consequently, any impairment of liver function, particularly in individuals with chronic liver disease, can lead to substantial alterations in iron regulation [3, 29]