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High homocysteine levels have been linked to an increased risk of heart disease, weaker bones, poor brain and kidney function, and premature death (3)

The clinical implication is that for children showing signs of mitochondrial weakness (low energy, post-exertional fatigue, regression with illness, abnormal organic acids markers, or borderline-low free carnitine on plasma testing), L-carnitine supplementation can be a meaningful adjunct

Fractures at diagnosis in infants and children with osteogenesis imperfecta

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