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the reduced dye then undergoes non-enzymic oxidation in air, so the addition of a relatively small amount of methylene blue will effectively deplete NADPH, and would be expected to stimulate any pathway that reduces NADP+ to NADPH

Other contributors to this work include Premranjan Kumar, Chun Liu, James W

The characteristic morning hobble becomes less severe, and the cumulative pain from a day on your feet diminishes noticeably