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Furthermore, it regulated the expression of purinergic receptors (including A2A, A3, P2X4, P2X7, and P2Y1), which are recognized for their significant roles in the inflammatory response associated with DED [77]

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Avocados are rich in seven-carbon sugars, primarily D-mannoheptulose and perseitol, with D-mannoheptulose offering protective effects against DM by mimicking caloric restriction, which delays aging and related diseases (459)