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10.1172/JCI90519 92 Santana-CodinaN.ManciasJ

(4) Cisplatin + LicoA (received LicoA at 5.0 mg/kg intragastrically daily plus Cisplatin, as per group 2)

Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling

These additions do not replace pharmacological PCT but can support overall recovery

5 Epigenetics in the interplay between the HPA axis and inflammation in depression Because depression is a psychiatric condition characterized by alterations in the HPA axis and inflammatory response regulation, investigating epigenetic mechanisms that modulate these processes is relevant (Figure 2)