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Selenium treatment in patients with Graves orbitopathy has been shown to delay disease progression and improve the quality of life

Again, the loss of correlations in the pathway metabolite may be lost in patients due to illness-related, and also perhaps treatment influences, on 5-HIAA, since the TRP5-HIAA correlation is appears weakened in patients (Yao et al., 2010a)

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Collectively, these data support a protective role of SIRT1 and SIRT3 in PD-associated pathways, while SIRT2 might show different functions from the former two