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It takes part in the metabolite damage-control systems of organisms [166]

In the 1960s, the concept of providing a person's complete nutritional needs through an IV solution began to be seriously considered

The urinary antiproliferative factor (APF), which has been recently identified in the context of IC, acts to hinder cell growth and disrupts the repair of the damaged or worn-away urothelium, leading to alterations in the barrier function of the bladder lining (Sant, 2002)

Active site residues U46, E48, Q81, and W136 are highlighted and shown as sticks