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It is harmless even in huge amounts: Ever since B12 was isolated as a substance, it has been used in extremely high doses to treat cyanide poisoning and a range of illnesses

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It is used to provide anesthesia for dental procedures and to relieve pain from various conditions, such as shingles, cancer, and labor

Patients experiencing persistent gastrointestinal adverse effects may benefit from slower titration schedules or maintaining lower doses for longer periods before attempting escalation

"The uncertain issue is how long that protection is going to last against the current variants, as well as some of the ones that might get selected for if you wait too long." Bhattacharya said delaying the second dose up to six weeks, in line with the CDC's guidance, seems reasonable