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238,239 Similarly, curcumin, a bioactive component of turmeric, has been reported to modulate neuroinflammatory responses by suppressing proinflammatory activation of microglia through regulation of the JAK2/STAT3 signaling axis in vitro

T-cell activation and lowered T regulatory cell numbers are key processes in severe major depressive disorder: effects of recurrence of illness and adverse childhood experiences

Brain Res Brain Res Rev (2001) 35(2):161204

The process of safely delivering copper to these enzymes is complex, and disruption of this process can lead to disease, particularly neu-rodegenerative disease

Consistent with these studies, Aspernig et al