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developed a series of ionizable lipids that contained two asymmetric hydrophobic tails (e.g., L021) (Figure 49)

for instance, B

Palmieri et al., 2010)

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Taken together, this reduces the likelihood that mitochondrial fragmentation in BIM-deficient cells is based on the same mechanism as in BAX/BAK-deficient cells, and suggests that the fragmentation is a consequence of increased glycolysis