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Animal LD50 studies in mice showed approximately 320 mg per kilogram of body weight, which translates to roughly 22,400 mg for a 154-pound human

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But...the fact remains that if you have symptoms which could be due to B12 deficency, then more frequent injections are required - thought the UK prescribing guidelines don't appear flexible enough to actually enable this (after loading doses and neurological regime - if needed - the only options seem to be eight weekly or three monthly