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While the summary effect for the sales/purchases studies in the meta-analysis of cigarette elasticity with respect to ENDS price did not reach statistical significance, the prevalence/frequency/other outcomes studies (those not included in the meta-analysis) reported a consistent, albeit not always significant, increase in adult cigarette smoking in response to higher ENDS price, suggesting substitution

The combined impact of these aging effects can be significant, leading to a prematurely aged appearance in smokers, often making them appear older than their actual age

Today 285 , 194203 (2017)

Cessation products such as nicotine replacement therapies (NRT) that are expressly for cessation or otherwise make therapeutic claims must be authorized by the Center for Drug Evaluation and Research approval process for safety and effectiveness