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This finding is consistent with Braaks theory, which postulates that PD disease may begin in the enteric nervous system (ENS) and then travel down the vagus nerve to the CNS (10)

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China 11

C.MyersonJ

Some researchers have recently proposed the potential origination of pathogenic alpha-synuclein proteins in the gastrointestinal tract (54), and transfer to the central nervous system via trans-synaptic cell-to-cell transmission in the vagal nerve