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Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15: Cell Reports Rather than a rejuvenating agent, GDF11 may have a detrimental effect on liver senescence. Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy [2021, open access] : r longevity Biochemistry and Biology of GDF11 and Myostatin Circulation Research GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration ScienceDirect GDF 11 10ug
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