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Furthermore, double KO mice receiving three weekly intravenous injections of hCitrinmRNALNPs showed an increased preference for voluntary sucrose consumption, indicative of a reduction in the canonical aversion to carbohydraterich foods associated with CD [118]

Su Z., Liu Y., Xia Z., Rustgi A

This stimulates the production of excessive testosterone by thecal cells, disrupting the hypothalamic-pituitary-ovarian (HPO) axis, ultimately affecting dominant follicle generation, follicular dysfunction, and ovarian interstitial cell fibrosis (51, 52)

The official prescribing information states that TPN Electrolytes are indicated for use as a supplement to nutritional solutions containing concentrated dextrose and amino acids delivered by central venous infusion, to help maintain electrolyte homeostasis in adult patients.

While no model fully recapitulates dry AMD, these two acute in vitro models effectively capture several key features observed in the RPE during the progression of AMD, thereby establishing a relevant platform for evaluating potential therapies for AMD and GA