glutathione increase platinum drugs

glutathione increase platinum drugs and taxanes: can we overcome resistance? AKR1C1 interacts with STAT3 to

Name: glutathione increase platinum drugs and taxanes: can we overcome resistance? AKR1C1 interacts with STAT3 to
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AKR1C1 interacts with STAT3 to increase intracellular glutathione and confers resistance to oxaliplatin in colorectal cancer ScienceDirect Platinum based drugs: past, present and future Cancer Chemotherapy and Pharmacology Springer Nature Link Glutathione Dependent Pathways in Cancer Cells Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy ACS Omega Glutathione Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation PMC

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Description

The sensor is part of a protein that does triple duty: it senses, regulates, and delivers the antioxidant glutathione into the mitochondrial interior, where it plays critical roles in tamping down oxidizing reactions and maintaining appropriate iron levels