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Neuroscience, 295 , 139150

The results were, to put it mildly, underwhelming

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The enzyme is therefore proposed to transition between the basal state in the absence of SAM and the SAM-bound activated state 15

While short-term fasting decreases serum IGF-I but does not affect GHBP (69), the triad of IGF-I deficiency, poor growth and pubertal delay/arrest in long term nutritional deficiency such as in anorexia nervosa is associated with low GHBP that is partly restored with weight gain (63)