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Chiang MC, Nicol CJB, Chen SJ, Huang RN (2022) TO901317 activation of LXR-dependent pathways mitigate amyloid-beta peptide-induced neurotoxicity in 3D human neural stem cell culture scaffolds and AD mice

Dysregulation of lipid metabolism emerged as a central pathway, with UPF consumption linked to altered fatty acid profiles, neuroinflammatory signaling, and impaired neurotransmitter systems, particularly those involving serotonin and dopamine

Five more peptides are scheduled for a later PCAC meeting before the end of February 2027

McLean et al., 2011) (see also Tables 1, 2)