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Although the clinical efficacy of vitamin B 6 and its effect on decreasing plasma total homocysteine are well established, the underlying mechanism is still unclear

Cigarette smoke-induced dysbiosis: comparative analysis of lung and intestinal microbiomes in COPD mice and patients

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However, activation of LXRs could be a double-edged sword, as LXRs are highly expressed in haematopoietic stem cells and myeloid progenitor cells, in which they decrease the proliferative responses to IL-3 and GM-CSF (Murphy et al., 2011)

Given the central role of the glucagon-GCGR pathway in glucose homeostasis, modulating this pathway has been proposed as a potential therapeutic strategy for diabetes treatment