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Milk thistle also contains a flavonoid complex which is important for protecting cells against free radical damage and inflammation

Experiments showed that knocking down FTO in adult hippocampal neurons induced depression-like behavior, while overexpressing FTO reversed such behavior in response to unpredictable chronic mild stress

Yuan et al., 2006

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Design of a randomized controlled trial to evaluate effectiveness of methotrexate versus prednisone as first-line treatment for pulmonary sarcoidosis: the PREDMETH study