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A separate category, including CJC-1295 and Sermorelin, works through growth-hormone stimulation instead of appetite signaling: these peptides prompt the pituitary gland to release more of the body's own growth hormone, which supports fat metabolism and helps preserve lean muscle during a calorie deficit

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Additionally, we reiterate what we stated in the CY 2025 PFS proposed rule (89 FR 61739), and wish to clarify in this final rule, and at 424.24(c)(5) with a minor amendment, that any reference to an order or referral at 424.24(c)(5) cannot be construed to require an order or referral for outpatient physical therapy, occupational therapy, or speech-language pathology services