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There are several reasons for this: Peak Absorption: With no food in your stomach, there is less competition for absorption

Your body doesnt store extra vitamin B12, so even high doses of vitamin B12 are considered safe

Production of some benzylisoquinoline alkaloids in Papaver armeniacum L

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The gases produced reduce the DAO enzyme that is responsible for breaking down histamine, as the gases damage the microvilli in our gut wall that stores DAO