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In OA cartilage, chondrocytes display alterations in mitochondrial activity, such as decreased ATP generation and increased oxidative stress, which can contribute to cartilage deterioration

Figure 1 4.2.1 Butyrate: a paradigm of concentration-dependent epigenetic immunomodulation via the concentration-cell-therapy axis Butyrate, a key gut microbial SCFA, embodies a unified concentration-cell type-therapy context framework that resolves its dual immunomodulatory effects, linking epigenetic regulation to therapeutic outcomes

In living cells, carnitine is needed to transport fatty acid mitochondria during the breakdown of lipids for metabolic energy generation

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Primordial follicles are activated when the Foxo3 protein, which is located far downstream, is phosphorylated