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5f) and elicited remarkable cell death under glucose starvation (Extended Data Fig

This protective effect was diminished by Sirt1 silencing or AKT inhibition, accompanied by enhanced Fe 2 and ROS fluorescence intensities, indicating that the Sirt1/AKT/FoxO3a pathway plays a critical role in Cur-mediated suppression of autophagy-dependent ferroptosis [194]

doi: 10.1016/j.ejmech.2018.08.062

The KD improves neuronal function by lowering glutamate toxicity, increasing GABA inhibitory tone, and decreasing reactive oxygen species (ROS) production [49]