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[00027] "Optional" or "optionally" as used herein means that the subsequently described event or circumstance can or cannot occur, and that the description includes instances where the event or circumstance occurs and instances where it does not

doi:10.1515/jcim-2014-0058

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Tumors can also hijack DC maturation to decrease MHC expression and destroy the costimulatory machinery by secreting suppressive factors such as TGF-, interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF) [110]