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wustl.edu Cellular mechanisms to clear misfolded proteins, and therapies to minimize toxicity by stimulating degradation of misfolded proteins As a physician-scientist, David Perlmutter is internationally recognized for his research on alpha-1 antitrypsin deficiency (ATD), a genetic disorder in which accumulations of a misfolded protein can cause severe liver damage

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doi: 10.1038/s41392-020-0191-1 11 WilkAJRustagiAZhaoNQRoqueJMartnez-ColnGJMcKechnieJLet al

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