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As used herein, the term "promoter" refers to a nucleic acid fragment that functions to control the transcription of one or more genes, located upstream with respect to the direction of transcription of the transcription initiation site of the gene, and is structurally identified by the presence of a binding site for DNA- dependent RNA polymerase, transcription initiation sites and any other DNA sequences, including, but not limited to transcription factor binding sites, repressor and activator protein binding sites, and any other sequences of nucleotides known to one of skill in the art to act directly or indirectly to regulate the amount of transcription from the promoter

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Biophysical properties of TRPM2 and TRPM7 The monomers of chanzymes TRPM2 and TRPM7 have largely common domain structures, these tetramers both operate as Ca 2+ -permeable cation channels with different biophysical properties, as summarized below