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Taken together, while these natural products exhibit potential biological activity relevant to DOR, current evidence remains preliminary and largely exploratory

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Tumor suppressor p53, a transcription factor that regulates the expression of stress response genes and mediates a variety of anti-proliferative processes, plays a dual role in ferroptosis [85]

RGP reduced AQP3 expression to inhibit the PI3K/Akt pathway, thereby promoting ACSL4-mediated ferroptosis in gastric cancer cells (Wang et al., 2024a)