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However, because DRD2 and Nrf2 are expressed in both neurons and astrocytes, chemicals targeting either of these targets can affect the physiological functions of neurons and result in unexpected side effects

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However, future controlled clinical studies are required to test the broad spectrum of the NAC effect and its mechanism of action in combination with conventional therapy in SLE patients

We acknowledge the CINECA award under the ELIXIR-V initiative, for the availability of high-performance computing resources and support