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Key to this approach are (i) the use of agreed reference products for comparison, ideally authorized MRTPs, and (ii) bridging methodologies that allow to compare a cMRTP with the reference products based on a limited number of studies (see challenge 4)

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Nicotine Dependence Dependence scores influenced appeal rankings of Silver (color), as lower dependence participants were more likely to rank Silver as top 3 appealing than higher dependence participants (32.7% vs 15.1%) [ 2 (9)=25.25, p=0.003]

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