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When protein misfolding occurs, there is another way of cell protection called the integrated stress response (ISR)

This is supported by the fact that the administration of recombinant IGF-1 abrogates pro-inflammatory cytokine-induced net protein loss and enhances peripheral glucose clearance in lambs [53], and that muscular protein synthesis is correlated with IGF-1 in immunity-challenged animals [54]

Anne Marie Zuchowski 1982 Anonymous Michael F

Some of the reported causes are as follows: (1) the high lipophilicity of these compounds such that low solubility in water that limits their absorption, (2) hepatic first-pass metabolism, (3) rapid metabolism, (4) irregular pharmacokinetics, (5) their instability in the presence of gastric pH, and (6) the influence of temperature [76,162,163,164]

4 Department of Clinical Pathology, Faculty of Medicine, Minia University, El-Minia, Egypt