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The Virginia is there, but it's almost like taking a bite of biscotti along with your unsweetened Italian espresso

The blend has a far higher proportion of black Cavendish than any other leaf

More specifically, the British National Formulary marks with bullet points potentially harmful drug pairs which should be prescribed cautiously, under appropriate monitoring, or avoided altogether (British National Formulary BNF, 2024)

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Symptoms of gangrene include black or blue skin, a loss of feeling in the affected finger or toe, and a bad smell from the area