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These advanced technologies hold promise to significantly enhance the accuracy of prediction models for high-altitude illnesses, improve individualized management effectiveness, and bolster real-time monitoring capabilities, thereby effectively reducing the incidence of these illnesses and enhancing treatment outcomes (Wang et al., 2023

it can invalidate the question the protocol was designed to answer

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In vitro , hPMSCs-Exos enhance tube formation and migration of human umbilical vein endothelial cells (HUVECs), while in vivo , they lead to significant increases in vascular density, volume fraction, and connectivity, alongside notable improvements in motor and sensory functions