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Two possible explanations were proposed

Angiogenesis forms new paths that deliver oxygen and nutrients directly to damaged tissues

Figure 2 3.1 Activation of inflammatory signaling pathways Research indicates that increased intestinal permeability allows endotoxins such as LPS to enter the systemic circulation, where they trigger systemic inflammatory responses by activating the Toll-like receptor 4/nuclear factor kappa-light-chain-enhancer of activated B cells (TLR4/NF-B) inflammatory pathway

Superoxide Dismutase, Catalase, & Glutathione Protect Blood Cells from Oxidative Stress & Damage Several powerful oxidants are produced during the course of metabolism, in both blood cells and most other cells of the body