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Budapest: Semmelweis kiad

Similarly, CdCl 2 , a chemical inhibitor of glutaredoxin, sensitized hepatocytes to TNF-mediated cytotoxicity

The anionic nature of superoxide and the fact that it is mostly produced in the mitochondrial matrix determine that the bulk of antioxidant defenses to neutralize superoxide and other ROS reside in the matrix

Carcinogenesis 8 , 861864 (1987)

The first line of defense against superoxide is the presence of a specific member of the family of metalloenzymes called superoxide dismutases (SODs), MnSOD or SOD2, specifically located in the mitochondrial matrix, which catalyzes the dismutation of superoxide anion into H 2 O 2 as shown in Figure 2